Antibiotics and Micronutritional Blend to Enhance Fertility Potential in Male Having Abnormal Semen Parameters

Objective: Objective of this study was to explore the effect of empirical antibiotics and micro nutritional blends in infertile men having idiopathic oligospermia, asthenospermia and oligoasthenospermia Materials and Methods: This prospective cross sectional study was undertaken in a tertiary level infertility care unit of Dhaka between September 2005 and December 2007. Two hundred and seven oligo, astheno and oligoasthenospermic patients were the target population for this study. Thorough infertility evaluation was done to identify idiopathic oligo, astheno and oligoasthenospermia. Female partners were also evaluated to exclude bilateral tubal blockage, pelvic inflammatory diseases, endometriosis, uterine pathology and resistant PCOS. Male partners were divided into three groups for I) Antibiotics and micronutrients, II) only micronutrients and III) no intervention as control. Treatment was continued for three months. Semen analysis was repeated at the end of two and three months. Main outcome measures were improvement of semen parameters and pregnancy rate. Results: Before treatment all patients’ characteristics were comparable. After treatment there was significant improvement both in count and motility in groups I and II p <0.05. In group III where there was no intervention there was no improvement of semen parameters p >0.05. Six patients (8.70%) from group I and 12 patients (17.29%) from group II got pregnant within 6 months of observation. No one got pregnant from group III. Conclusion: Empirical use of antibiotics and micronutrients in idiopathic oligo, astheno and oligoasthenospemia can improve sperm quantity and quality and aid a couple in achieving pregnancy.